ELND005 References
Shankar et al., Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory, Nature Medicine, 2008 Aug;14(8):837-42.
Berman et al., Oligomeric amyloid-beta peptide disrupts phosphatidylinositol-4,5-bisphosphae metabolism, Nature Neuroscience, 2008 May;11(5):547-54.
McLaurin et al., Cyclohexanehexol inhibitors of beta Amyloid aggregation prevent and reverse Alzheimer phenotype in a mouse model, Nature Medicine, 2006 Jul;12(7):801-8.
McLaurin et al., Inositol stereoisomers stabilize an oligomeric aggregate of Alzheimer amyloid-beta peptide and inhibit A-beta-induced toxicity, Journal of Biological Chemistry, 2000 Jun 16;275(24):18495-502.
JoAnne McLaurin, Properties of scyllo-inositol as a therapeutic treatment of AD-like pathology, Journal of Molecular Medicine, 2007 Jun;85(6):603-11.
Townsend et al., Orally available compound prevents deficits in memory caused by the Alzheimer amyloid-beta oligomers, Annals of Neurology, 2006 Dec;60(6):668-76.
Berman et al., Oligomeric amyloid-beta peptide disrupts phosphatidylinositol-4,5-bisphosphae metabolism, Nature Neuroscience, 2008 May;11(5):547-54.
McLaurin et al., Cyclohexanehexol inhibitors of beta Amyloid aggregation prevent and reverse Alzheimer phenotype in a mouse model, Nature Medicine, 2006 Jul;12(7):801-8.
McLaurin et al., Inositol stereoisomers stabilize an oligomeric aggregate of Alzheimer amyloid-beta peptide and inhibit A-beta-induced toxicity, Journal of Biological Chemistry, 2000 Jun 16;275(24):18495-502.
JoAnne McLaurin, Properties of scyllo-inositol as a therapeutic treatment of AD-like pathology, Journal of Molecular Medicine, 2007 Jun;85(6):603-11.
Townsend et al., Orally available compound prevents deficits in memory caused by the Alzheimer amyloid-beta oligomers, Annals of Neurology, 2006 Dec;60(6):668-76.
Gastrin-Based Therapy References
Suarez-Pinzon WL, Rabinovitch A., Combination therapy with epidermal growth factor and gastrin delays autoimmune diabetes recurrence in nonobese diabetic mice transplanted with syngeneic islets. Transplant Proc. 2008 Mar;40(2):529-32.
Susan Bonner-Weir & Gordon C Weir, New sources of pancreatic beta cells, Nature Biotechnology, 2005 Jul;23(7):857-61.
Brand et al., Pharmacological treatment of chronic diabetes by stimulating pancreatic beta-cell regeneration with systemic co-administration of EGF and gastrin, Pharmacology & Toxicology, 2002 Dec;91(6):414-20.
Rooman et al., Gastrin stimulates beta-cell neogenesis and increases islet mass from transdifferentiated but not from normal exocrine pancreas tissue, Diabetes, 2002 Mar;51(3):686-90.
Rooman et al., Combined gastrin and epidermal growth factor treatment induces islet regeneration and restores normoglycaemia in C57Bl6/J mice treated with alloxan, Diabetologia, 2004 Feb;47(2):259-65.
Suarez-Pinzon WL et al., Combination therapy with epidermal growth factor and gastrin increases beta-cell mass and reverses hyperglycemia in diabetic NOD mice, Diabetes, 2005 Sep;54(9):2596-601.
Suarez-Pinzon WL et al., Combination therapy with epidermal growth factor and gastrin induces neogenesis of human islet {beta}-cells from pancreatic duct cells and an increase in functional {beta}-cell mass, Journal of Clinical Endocrinology and Metabolism, 2005 Jun;90(6):3401-9.
Robert S. Dinsmoor, The endless possibilities of beta cell regeneration, JDRF Countdown, 2005.
Susan Bonner-Weir & Gordon C Weir, New sources of pancreatic beta cells, Nature Biotechnology, 2005 Jul;23(7):857-61.
Brand et al., Pharmacological treatment of chronic diabetes by stimulating pancreatic beta-cell regeneration with systemic co-administration of EGF and gastrin, Pharmacology & Toxicology, 2002 Dec;91(6):414-20.
Rooman et al., Gastrin stimulates beta-cell neogenesis and increases islet mass from transdifferentiated but not from normal exocrine pancreas tissue, Diabetes, 2002 Mar;51(3):686-90.
Rooman et al., Combined gastrin and epidermal growth factor treatment induces islet regeneration and restores normoglycaemia in C57Bl6/J mice treated with alloxan, Diabetologia, 2004 Feb;47(2):259-65.
Suarez-Pinzon WL et al., Combination therapy with epidermal growth factor and gastrin increases beta-cell mass and reverses hyperglycemia in diabetic NOD mice, Diabetes, 2005 Sep;54(9):2596-601.
Suarez-Pinzon WL et al., Combination therapy with epidermal growth factor and gastrin induces neogenesis of human islet {beta}-cells from pancreatic duct cells and an increase in functional {beta}-cell mass, Journal of Clinical Endocrinology and Metabolism, 2005 Jun;90(6):3401-9.
Robert S. Dinsmoor, The endless possibilities of beta cell regeneration, JDRF Countdown, 2005.
